6-azauridine in combination chemotherapy of childhood acute myelocytic leukemia

Chemotherapy of acute myelocytic leukemia in children.

Acute myelocytic leukemia (AML) in both children and adults is a more complex and resistant disease than acute lymphocytic leukemia. Progress has been slower and therapy more complicated, but with intensive myelosuppressive induction and further postremission therapy one-third of such patients may now achieve longterm survival and probably be cured.’-5 In the Nordic countries (Denmark, Finland,...

Prediction of response to chemotherapy in acute myelocytic leukemia.

Marrow specimens obtained from 23 patients with acute myelocytic leukemia were exposed to cytosine arabinoside and/or daunorubicin in vitro, and the effects of these agents on colony formation in vitro was determined. Thymidine suicide indices were determined as well, which permitted a distinction to be made between kinetic and metabolic resistance to cytosine arabinoside. The sensitivity of th...

Evaluating Protective Effects of Silymarin on Liver and Cardiac Side Effects of Chemotherapy Drugs in Childhood Acute Lymphoblastic Leukemia

Background: The protective effects of silymarin on liver and heart have been investigated and identified by many researchers. This study evaluates the protective effects of this substance on hepatotoxicity and cardiotoxcity of chemotherapy drugs in leukemic children. Materials and Methods: In this study, 71 children, aging 2-14 years old, going through the maintenance phase of acute lymphoblas...

Asparaginase in combination chemotherapy for remission induction of childhood acute lymphocytic leukemia.

Daunorubicin metabolism in acute myelocytic leukemia.

mic enzyme that converts daunorubicm to a principal metabolite, daunorubicino!, in the presence of NADPH. This enzyme, found in mammalian tissues and studied in rat tissue preparations and normal human blood components, is also present in human leukemic myeloblasts. The enzymes from both normal and leukemic leukocytes require NADPH for activity, have similar kinetics and substrate saturation ch...